There is a long list of 278 institutional holders of ACAD within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of ACAD by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-ACAD table below, the initial column indicates the name of each top institutional holder of ACAD, with a link to that fund's top holdings. The next columns indicate the amount of ACAD stock held by each of the institutional holders of ACAD, followed by the ACAD position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
Baker BROS. Advisors LP	42,864,612	$1,342,091	12/31/2023
ACAD	42,864,612	$1,342,091	12/31/2023
Vanguard Group Inc.	13,396,009	$419,429	12/31/2023
ACAD	13,396,009	$419,429	12/31/2023
BlackRock Inc.	11,410,483	$357,262	12/31/2023
ACAD	11,410,483	$357,262	12/31/2023
RTW Investments LP	11,253,551	$352,349	12/31/2023
ACAD	11,253,551	$352,349	12/31/2023
State Street Corp	6,465,026	$202,420	12/31/2023
ACAD	6,465,026	$202,420	12/31/2023
EcoR1 Capital LLC	5,991,479	$187,593	12/31/2023
ACAD	5,991,479	$187,593	12/31/2023
FMR LLC	5,265,358	$164,858	12/31/2023
ACAD	5,265,358	$164,858	12/31/2023
Price T Rowe Associates Inc. MD	5,178,509	$162,140	12/31/2023
ACAD	5,178,509	$162,140	12/31/2023
D. E. Shaw & Co. Inc.	3,754,598	$117,556	12/31/2023
ACAD	3,754,598	$117,556	12/31/2023
Fred Alger Management LLC	3,176,775	$99,465	12/31/2023
ACAD	3,176,775	$99,465	12/31/2023
Geode Capital Management LLC	2,692,152	$84,300	12/31/2023
ACAD	2,692,152	$84,300	12/31/2023
Palo Alto Investors LP	2,409,556	$75,443	12/31/2023
ACAD	2,409,556	$75,443	12/31/2023
First Trust Advisors LP	1,777,307	$55,647	12/31/2023
ACAD	1,777,307	$55,647	12/31/2023
Millennium Management LLC	1,764,678	$55,252	12/31/2023
ACAD	1,764,678	$55,252	12/31/2023
Emerald Advisers LLC	1,645,565	$51,523	12/31/2023
ACAD	1,645,565	$51,523	12/31/2023
Pictet Asset Management Holding SA	1,461,232	$45,751	12/31/2023
ACAD	1,461,232	$45,751	12/31/2023
Norges Bank	1,443,218	$45,187	12/31/2023
ACAD	1,443,218	$45,187	12/31/2023
Morgan Stanley	1,361,900	$42,641	12/31/2023
ACAD	1,361,900	$42,641	12/31/2023
Jupiter Asset Management Ltd.	1,322,364	$41,403	12/31/2023
ACAD	1,322,364	$41,403	12/31/2023
Emerald Mutual Fund Advisers Trust	1,304,556	$40,846	12/31/2023
ACAD	1,304,556	$40,846	12/31/2023
Voloridge Investment Management LLC	1,282,177	$40,145	12/31/2023
ACAD	1,282,177	$40,145	12/31/2023
Northern Trust Corp	1,214,133	$38,015	12/31/2023
ACAD	1,214,133	$38,015	12/31/2023
Charles Schwab Investment Management Inc.	1,127,907	$35,315	12/31/2023
ACAD	1,127,907	$35,315	12/31/2023
Deutsche Bank AG	1,025,425	$32,106	12/31/2023
ACAD	1,025,425	$32,106	12/31/2023
The Manufacturers Life Insurance Company	846,028	$26,489	12/31/2023
ACAD	846,028	$26,489	12/31/2023
Frontier Capital Management Co. LLC	823,586	$25,786	12/31/2023
ACAD	823,586	$25,786	12/31/2023
Eventide Asset Management LLC	809,391	$25,342	12/31/2023
ACAD	809,391	$25,342	12/31/2023
Finepoint Capital LP	769,653	$24,098	12/31/2023
ACAD	769,653	$24,098	12/31/2023
Goldman Sachs Group Inc.		$23,736	12/31/2023
ACAD	804,170	$25,179	12/31/2023
Put	46,100	$1,443	12/31/2023
Frazier Life Sciences Management L.P.	730,917	$22,885	12/31/2023
ACAD	730,917	$22,885	12/31/2023
JPMorgan Chase & Co.	660,900	$20,693	12/31/2023
ACAD	660,900	$20,693	12/31/2023
Ameriprise Financial Inc.	647,112	$20,261	12/31/2023
ACAD	647,112	$20,261	12/31/2023
Panagora Asset Management Inc.	644,920	$20,192	12/31/2023
ACAD	644,920	$20,192	12/31/2023
Fuller & Thaler Asset Management Inc.	641,185	$20,075	12/31/2023
ACAD	641,185	$20,075	12/31/2023
Connor Clark & Lunn Investment Management Ltd.	627,384	$19,643	12/31/2023
ACAD	627,384	$19,643	12/31/2023
Nordea Investment Management AB	586,002	$18,547	12/31/2023
ACAD	586,002	$18,547	12/31/2023
Alyeska Investment Group L.P.	585,036	$18,317	12/31/2023
ACAD	585,036	$18,317	12/31/2023
Rockefeller Capital Management L.P.	556,337	$17,419	12/31/2023
ACAD	556,337	$17,419	12/31/2023
Bank of America Corp DE		$15,981	12/31/2023
ACAD	507,687	$15,896	12/31/2023
Call	2,700	$85	12/31/2023
Woodline Partners LP	474,159	$14,846	12/31/2023
ACAD	474,159	$14,846	12/31/2023
Healthcare of Ontario Pension Plan Trust Fund	471,000	$14,747	12/31/2023
ACAD	471,000	$14,747	12/31/2023
Prudential Financial Inc.	443,116	$13,874	12/31/2023
ACAD	443,116	$13,874	12/31/2023
Susquehanna International Group LLP		$13,622	12/31/2023
ACAD	375,263	$11,749	12/31/2023
Call	147,900	$4,631	12/31/2023
Put	88,100	$2,758	12/31/2023
Rafferty Asset Management LLC	427,930	$13,398	12/31/2023
ACAD	427,930	$13,398	12/31/2023
Invesco Ltd.	422,969	$13,243	12/31/2023
ACAD	422,969	$13,243	12/31/2023
Nuveen Asset Management LLC	417,072	$13,059	12/31/2023
ACAD	417,072	$13,059	12/31/2023
Balyasny Asset Management LLC		$12,551	12/31/2023
ACAD	300,875	$9,420	12/31/2023
Call	100,000	$3,131	12/31/2023
Jane Street Group LLC		$12,361	12/31/2023
ACAD	446,317	$13,974	12/31/2023
Put	80,000	$2,505	12/31/2023
Call	28,500	$892	12/31/2023
Point72 Asset Management L.P.	392,827	$12,299	12/31/2023
ACAD	392,827	$12,299	12/31/2023
Rice Hall James & Associates LLC	664,556	$12,288	03/31/2024
ACAD	664,556	$12,288	03/31/2024