There is a long list of 69 institutional holders of TYRA within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of TYRA by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-TYRA table below, the initial column indicates the name of each top institutional holder of TYRA, with a link to that fund's top holdings. The next columns indicate the amount of TYRA stock held by each of the institutional holders of TYRA, followed by the TYRA position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
RA Capital Management L.P.	7,236,454	$100,225	12/31/2023
TYRA	7,236,454	$100,225	12/31/2023
Boxer Capital LLC	6,448,359	$89,310	12/31/2023
TYRA	6,448,359	$89,310	12/31/2023
Canaan Partners XI LLC	4,409,991	$72,324	03/31/2024
TYRA	4,409,991	$72,324	03/31/2024
FMR LLC	2,768,696	$38,346	12/31/2023
TYRA	2,768,696	$38,346	12/31/2023
BVF Inc. IL	2,739,595	$37,943	12/31/2023
TYRA	2,739,595	$37,943	12/31/2023
Nextech Invest AG	2,518,582	$34,882	12/31/2023
TYRA	2,518,582	$34,882	12/31/2023
TCG Crossover Management LLC	1,989,103	$27,549	12/31/2023
TYRA	1,989,103	$27,549	12/31/2023
Fairmount Funds Management LLC	1,393,329	$19,298	12/31/2023
TYRA	1,393,329	$19,298	12/31/2023
Frazier Life Sciences Management L.P.	1,026,420	$14,216	12/31/2023
TYRA	1,026,420	$14,216	12/31/2023
BlackRock Inc.	965,034	$13,366	12/31/2023
TYRA	965,034	$13,366	12/31/2023
Vanguard Group Inc.	758,967	$10,512	12/31/2023
TYRA	758,967	$10,512	12/31/2023
5AM Venture Management LLC	554,979	$7,686	12/31/2023
TYRA	554,979	$7,686	12/31/2023
JPMorgan Chase & Co.	401,706	$5,564	12/31/2023
TYRA	401,706	$5,564	12/31/2023
Perceptive Advisors LLC	360,000	$4,986	12/31/2023
TYRA	360,000	$4,986	12/31/2023
Kynam Capital Management LP	340,190	$4,712	12/31/2023
TYRA	340,190	$4,712	12/31/2023
Geode Capital Management LLC	333,469	$4,619	12/31/2023
TYRA	333,469	$4,619	12/31/2023
State Street Corp	265,354	$3,675	12/31/2023
TYRA	265,354	$3,675	12/31/2023
Driehaus Capital Management LLC	203,709	$2,821	12/31/2023
TYRA	203,709	$2,821	12/31/2023
Northern Trust Corp	152,250	$2,109	12/31/2023
TYRA	152,250	$2,109	12/31/2023
EcoR1 Capital LLC	137,014	$1,898	12/31/2023
TYRA	137,014	$1,898	12/31/2023
Charles Schwab Investment Management Inc.	110,537	$1,531	12/31/2023
TYRA	110,537	$1,531	12/31/2023
Wellington Management Group LLP	102,436	$1,419	12/31/2023
TYRA	102,436	$1,419	12/31/2023
Auour Investments LLC	85,020	$1,136	12/31/2023
TYRA	85,020	$1,136	12/31/2023
Susquehanna International Group LLP		$1,107	12/31/2023
Call	79,900	$1,107	12/31/2023
Bank of New York Mellon Corp	43,735	$717	03/31/2024
TYRA	43,735	$717	03/31/2024
Victory Capital Management Inc.	50,220	$696	12/31/2023
TYRA	50,220	$696	12/31/2023
Ikarian Capital LLC	48,170	$667	12/31/2023
TYRA	48,170	$667	12/31/2023
Morgan Stanley	35,668	$494	12/31/2023
TYRA	35,668	$494	12/31/2023
Marshall Wace LLP	30,001	$416	12/31/2023
TYRA	30,001	$416	12/31/2023
Nuveen Asset Management LLC	25,713	$356	12/31/2023
TYRA	25,713	$356	12/31/2023
Legato Capital Management LLC	20,259	$332	03/31/2024
TYRA	20,259	$332	03/31/2024
Mariner LLC	22,164	$307	12/31/2023
TYRA	22,164	$307	12/31/2023
Bank of America Corp DE	22,118	$306	12/31/2023
TYRA	22,118	$306	12/31/2023
Rhumbline Advisers	21,332	$295	12/31/2023
TYRA	21,332	$295	12/31/2023
Barclays PLC	19,227	$266	12/31/2023
TYRA	19,227	$266	12/31/2023
Exchange Traded Concepts LLC	16,053	$263	03/31/2024
TYRA	16,053	$263	03/31/2024
Fishman Jay A Ltd. MI	15,000	$246	03/31/2024
TYRA	15,000	$246	03/31/2024
Group One Trading L.P.		$245	12/31/2023
Call	17,700	$245	12/31/2023
Belvedere Trading LLC		$199	12/31/2023
Call	14,400	$199	12/31/2023
American Century Companies Inc.	10,880	$151	12/31/2023
TYRA	10,880	$151	12/31/2023
Dimensional Fund Advisors LP	10,609	$147	12/31/2023
TYRA	10,609	$147	12/31/2023
Baker BROS. Advisors LP	10,607	$147	12/31/2023
TYRA	10,607	$147	12/31/2023
Sepio Capital LP	10,625	$147	12/31/2023
TYRA	10,625	$147	12/31/2023
LPL Financial LLC	10,500	$145	12/31/2023
TYRA	10,500	$145	12/31/2023
Artia Global Partners LP	10,253	$142	12/31/2023
TYRA	10,253	$142	12/31/2023
Acuta Capital Partners LLC	8,867	$123	12/31/2023
TYRA	8,867	$123	12/31/2023
MetLife Investment Management LLC	7,702	$107	12/31/2023
TYRA	7,702	$107	12/31/2023
American International Group Inc.	6,951	$96	12/31/2023
TYRA	6,951	$96	12/31/2023
Deutsche Bank AG	6,223	$86	12/31/2023
TYRA	6,223	$86	12/31/2023
UBS Group AG	4,977	$69	12/31/2023
TYRA	4,977	$69	12/31/2023