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Holder Amount Position Size ($ in 1000's)  As of Novo Holdings A S 6,722,336 $19,696  12/31/2023      SPRB 6,722,336 $19,696  12/31/2023 RiverVest Venture Management LLC 2,936,281 $8,603  12/31/2023      SPRB 2,936,281 $8,603  12/31/2023 Carlyle Group Inc. 2,896,518 $8,371  12/31/2023      SPRB 2,896,518 $8,371  12/31/2023 Rock Springs Capital Management LP 2,609,125 $7,645  12/31/2023      SPRB 2,609,125 $7,645  12/31/2023 5AM Venture Management LLC 2,364,000 $6,927  12/31/2023      SPRB 2,364,000 $6,927  12/31/2023 Armistice Capital LLC 2,230,000 $6,534  12/31/2023      SPRB 2,230,000 $6,534  12/31/2023 Omega Fund Management LLC 2,161,022 $6,332  12/31/2023      SPRB 2,161,022 $6,332  12/31/2023 AIGH Capital Management LLC 2,123,863 $6,223  12/31/2023      SPRB 2,123,863 $6,223  12/31/2023 Aisling Capital Management LP 1,205,511 $3,532  12/31/2023      SPRB 1,205,511 $3,532  12/31/2023 Vanguard Group Inc. 822,390 $2,410  12/31/2023      SPRB 822,390 $2,410  12/31/2023 Sands Capital Ventures LLC 787,007 $2,306  12/31/2023      SPRB 787,007 $2,306  12/31/2023 DAFNA Capital Management LLC 548,510 $1,607  12/31/2023      SPRB 548,510 $1,607  12/31/2023 Worth Venture Partners LLC 526,933 $1,544  12/31/2023      SPRB 526,933 $1,544  12/31/2023 Millennium Management LLC 510,441 $1,496  12/31/2023      SPRB 510,441 $1,496  12/31/2023 Rosalind Advisors Inc. 1,508,419 $1,185  03/31/2024      SPRB 1,508,419 $1,185  03/31/2024 Alyeska Investment Group L.P. 400,000 $1,172  12/31/2023      SPRB 400,000 $1,172  12/31/2023 Acuitas Investments LLC 275,085 $806  12/31/2023      SPRB 275,085 $806  12/31/2023 BlackRock Inc. 261,016 $765  12/31/2023      SPRB 261,016 $765  12/31/2023 Renaissance Technologies LLC 185,100 $542  12/31/2023      SPRB 185,100 $542  12/31/2023 Geode Capital Management LLC 167,404 $491  12/31/2023      SPRB 167,404 $491  12/31/2023 Two Sigma Investments LP 134,357 $394  12/31/2023      SPRB 134,357 $394  12/31/2023 Superstring Capital Management LP 118,814 $348  12/31/2023      SPRB 118,814 $348  12/31/2023 Citadel Advisors LLC 108,240 $317  12/31/2023      SPRB 108,240 $317  12/31/2023 Marshall Wace LLP 105,721 $310  12/31/2023      SPRB 105,721 $310  12/31/2023 Northern Trust Corp 96,688 $283  12/31/2023      SPRB 96,688 $283  12/31/2023 Two Sigma Advisers LP 95,600 $280  12/31/2023      SPRB 95,600 $280  12/31/2023 Bridgeway Capital Management Inc. 85,000 $249  12/31/2023      SPRB 85,000 $249  12/31/2023 State Street Corp 61,993 $182  12/31/2023      SPRB 61,993 $182  12/31/2023 Marquette Asset Management LLC 55,757 $163  12/31/2023      SPRB 55,757 $163  12/31/2023 Privium Fund Management UK Ltd 24,554 $72  12/31/2023      SPRB 24,554 $72  12/31/2023 Sofinnova Investments Inc. 22,767 $67  12/31/2023      SPRB 22,767 $67  12/31/2023 Charles Schwab Investment Management Inc. 15,289 $45  12/31/2023      SPRB 15,289 $45  12/31/2023 Royal Bank of Canada 8,907 $26  12/31/2023      SPRB 8,907 $26  12/31/2023 Simplex Trading LLC   $21  03/31/2024      SPRB 28,100 $22  03/31/2024      Put 1,500 $1  03/31/2024      Call 200 $0  03/31/2024 Morgan Stanley 2,133 $6  12/31/2023      SPRB 2,133 $6  12/31/2023 Caldwell Sutter Capital Inc. 1,000 $1  03/31/2024      SPRB 1,000 $1  03/31/2024 UBS Group AG 485 $1  12/31/2023      SPRB 485 $1  12/31/2023 JPMorgan Chase & Co. 11 $0  12/31/2023      SPRB 11 $0  12/31/2023 Bank of America Corp DE 13 $0  12/31/2023      SPRB 13 $0  12/31/2023 Wells Fargo & Company MN 141 $0  12/31/2023      SPRB 141 $0  12/31/2023 Proequities Inc. 0 $0  12/31/2023      SPRB 0 $0  12/31/2023 See All: Funds Holding SPRB See Details: Top 10 Hedge Funds Holding SPRB Also See: SPRB Insider Buying Also See: SPRB Holdings Changes

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