On this page, we present all of the funds holding SPRB from our database of 13F filers, detailed in the table below. The first column indicates the name of each of the funds holding SPRB, with a link to that fund's top holdings. The next columns indicate the amount of SPRB stock held by each of the funds holding SPRB, followed by the SPRB position size held by the fund, and lastly the date of the quarterly filing period the data represents. In total, we count 40 funds holding SPRB within the last two filing periods in our coverage universe of 13F filers, with the largest position size having been reported by Novo Holdings A S. For more details on the positions held by Novo Holdings A S (or by any of the other funds holding SPRB), click the fund name in the "Holder" column of the funds-holding-SPRB table below.

Holder	Amount	Position Size ($ in 1000's)	As of
Novo Holdings A S	6,722,336	$19,696	12/31/2023
SPRB	6,722,336	$19,696	12/31/2023
RiverVest Venture Management LLC	2,936,281	$8,603	12/31/2023
SPRB	2,936,281	$8,603	12/31/2023
Carlyle Group Inc.	2,896,518	$8,371	12/31/2023
SPRB	2,896,518	$8,371	12/31/2023
Rock Springs Capital Management LP	2,609,125	$7,645	12/31/2023
SPRB	2,609,125	$7,645	12/31/2023
5AM Venture Management LLC	2,364,000	$6,927	12/31/2023
SPRB	2,364,000	$6,927	12/31/2023
Armistice Capital LLC	2,230,000	$6,534	12/31/2023
SPRB	2,230,000	$6,534	12/31/2023
Omega Fund Management LLC	2,161,022	$6,332	12/31/2023
SPRB	2,161,022	$6,332	12/31/2023
AIGH Capital Management LLC	2,123,863	$6,223	12/31/2023
SPRB	2,123,863	$6,223	12/31/2023
Rosalind Advisors Inc.	1,586,392	$4,648	12/31/2023
SPRB	1,586,392	$4,648	12/31/2023
Aisling Capital Management LP	1,205,511	$3,532	12/31/2023
SPRB	1,205,511	$3,532	12/31/2023
Vanguard Group Inc.	822,390	$2,410	12/31/2023
SPRB	822,390	$2,410	12/31/2023
Sands Capital Ventures LLC	787,007	$2,306	12/31/2023
SPRB	787,007	$2,306	12/31/2023
DAFNA Capital Management LLC	548,510	$1,607	12/31/2023
SPRB	548,510	$1,607	12/31/2023
Worth Venture Partners LLC	526,933	$1,544	12/31/2023
SPRB	526,933	$1,544	12/31/2023
Millennium Management LLC	510,441	$1,496	12/31/2023
SPRB	510,441	$1,496	12/31/2023
Alyeska Investment Group L.P.	400,000	$1,172	12/31/2023
SPRB	400,000	$1,172	12/31/2023
Acuitas Investments LLC	275,085	$806	12/31/2023
SPRB	275,085	$806	12/31/2023
BlackRock Inc.	261,016	$765	12/31/2023
SPRB	261,016	$765	12/31/2023
Renaissance Technologies LLC	185,100	$542	12/31/2023
SPRB	185,100	$542	12/31/2023
Geode Capital Management LLC	167,404	$491	12/31/2023
SPRB	167,404	$491	12/31/2023
Two Sigma Investments LP	134,357	$394	12/31/2023
SPRB	134,357	$394	12/31/2023
Superstring Capital Management LP	118,814	$348	12/31/2023
SPRB	118,814	$348	12/31/2023
Citadel Advisors LLC	108,240	$317	12/31/2023
SPRB	108,240	$317	12/31/2023
Marshall Wace LLP	105,721	$310	12/31/2023
SPRB	105,721	$310	12/31/2023
Northern Trust Corp	96,688	$283	12/31/2023
SPRB	96,688	$283	12/31/2023
Two Sigma Advisers LP	95,600	$280	12/31/2023
SPRB	95,600	$280	12/31/2023
Bridgeway Capital Management Inc.	85,000	$249	12/31/2023
SPRB	85,000	$249	12/31/2023
State Street Corp	61,993	$182	12/31/2023
SPRB	61,993	$182	12/31/2023
Marquette Asset Management LLC	55,757	$163	12/31/2023
SPRB	55,757	$163	12/31/2023
Privium Fund Management UK Ltd	24,554	$72	12/31/2023
SPRB	24,554	$72	12/31/2023
Sofinnova Investments Inc.	22,767	$67	12/31/2023
SPRB	22,767	$67	12/31/2023
Charles Schwab Investment Management Inc.	15,289	$45	12/31/2023
SPRB	15,289	$45	12/31/2023
Royal Bank of Canada	8,907	$26	12/31/2023
SPRB	8,907	$26	12/31/2023
Morgan Stanley	2,133	$6	12/31/2023
SPRB	2,133	$6	12/31/2023
Caldwell Sutter Capital Inc.	1,000	$1	03/31/2024
SPRB	1,000	$1	03/31/2024
UBS Group AG	485	$1	12/31/2023
SPRB	485	$1	12/31/2023
JPMorgan Chase & Co.	11	$0	12/31/2023
SPRB	11	$0	12/31/2023
Bank of America Corp DE	13	$0	12/31/2023
SPRB	13	$0	12/31/2023
Wells Fargo & Company MN	141	$0	12/31/2023
SPRB	141	$0	12/31/2023
Proequities Inc.	0	$0	12/31/2023
SPRB	0	$0	12/31/2023
Qube Research & Technologies Ltd	2	$0	12/31/2023
SPRB	2	$0	12/31/2023