There is a long list of 200 institutional holders of SAGE within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of SAGE by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-SAGE table below, the initial column indicates the name of each top institutional holder of SAGE, with a link to that fund's top holdings. The next columns indicate the amount of SAGE stock held by each of the institutional holders of SAGE, followed by the SAGE position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
Wellington Management Group LLP	6,061,996	$131,363	12/31/2023
SAGE	6,061,996	$131,363	12/31/2023
FMR LLC	5,482,477	$118,805	12/31/2023
SAGE	5,482,477	$118,805	12/31/2023
Vanguard Group Inc.	5,319,360	$115,271	12/31/2023
SAGE	5,319,360	$115,271	12/31/2023
RTW Investments LP	5,197,019	$112,619	12/31/2023
SAGE	5,197,019	$112,619	12/31/2023
BlackRock Inc.	4,663,900	$101,067	12/31/2023
SAGE	4,663,900	$101,067	12/31/2023
State Street Corp	3,918,222	$84,908	12/31/2023
SAGE	3,918,222	$84,908	12/31/2023
Bellevue Group AG	3,513,351	$76,134	12/31/2023
SAGE	3,513,351	$76,134	12/31/2023
JPMorgan Chase & Co.	1,670,715	$36,204	12/31/2023
SAGE	1,670,715	$36,204	12/31/2023
Cowen AND Company LLC	1,339,971	$29,037	12/31/2023
SAGE	1,339,971	$29,037	12/31/2023
Geode Capital Management LLC	1,167,257	$25,297	12/31/2023
SAGE	1,167,257	$25,297	12/31/2023
Deutsche Bank AG	1,027,755	$22,271	12/31/2023
SAGE	1,027,755	$22,271	12/31/2023
Palo Alto Investors LP	991,525	$21,486	12/31/2023
SAGE	991,525	$21,486	12/31/2023
Dimensional Fund Advisors LP	967,685	$20,971	12/31/2023
SAGE	967,685	$20,971	12/31/2023
Morgan Stanley	870,564	$18,865	12/31/2023
SAGE	870,564	$18,865	12/31/2023
Samlyn Capital LLC	768,902	$16,662	12/31/2023
SAGE	768,902	$16,662	12/31/2023
Jacobs Levy Equity Management Inc.	742,858	$16,098	12/31/2023
SAGE	742,858	$16,098	12/31/2023
Northern Trust Corp	542,656	$11,759	12/31/2023
SAGE	542,656	$11,759	12/31/2023
Price T Rowe Associates Inc. MD	478,129	$10,362	12/31/2023
SAGE	478,129	$10,362	12/31/2023
Goldman Sachs Group Inc.	476,506	$10,326	12/31/2023
SAGE	476,506	$10,326	12/31/2023
Citadel Advisors LLC		$10,179	12/31/2023
SAGE	433,130	$9,386	12/31/2023
Call	70,900	$1,536	12/31/2023
Put	34,300	$743	12/31/2023
Fisher Asset Management LLC	431,925	$9,360	12/31/2023
SAGE	431,925	$9,360	12/31/2023
Charles Schwab Investment Management Inc.	413,905	$8,969	12/31/2023
SAGE	413,905	$8,969	12/31/2023
Hudson Bay Capital Management LP	395,000	$8,560	12/31/2023
SAGE	395,000	$8,560	12/31/2023
Voloridge Investment Management LLC	392,699	$8,510	12/31/2023
SAGE	392,699	$8,510	12/31/2023
Susquehanna International Group LLP		$7,986	12/31/2023
SAGE	257,647	$5,583	12/31/2023
Call	157,100	$3,404	12/31/2023
Put	46,200	$1,001	12/31/2023
BNP Paribas Arbitrage SA	336,096	$7,283	12/31/2023
SAGE	336,096	$7,283	12/31/2023
Millennium Management LLC	333,203	$7,221	12/31/2023
SAGE	333,203	$7,221	12/31/2023
Ameriprise Financial Inc.	308,735	$6,690	12/31/2023
SAGE	308,735	$6,690	12/31/2023
Rafferty Asset Management LLC	306,914	$6,651	12/31/2023
SAGE	306,914	$6,651	12/31/2023
Norges Bank	292,294	$6,334	12/31/2023
SAGE	292,294	$6,334	12/31/2023
Bank of America Corp DE	269,551	$5,841	12/31/2023
SAGE	269,551	$5,841	12/31/2023
D. E. Shaw & Co. Inc.	254,667	$5,519	12/31/2023
SAGE	254,667	$5,519	12/31/2023
Two Sigma Investments LP	248,972	$5,395	12/31/2023
SAGE	248,972	$5,395	12/31/2023
DAFNA Capital Management LLC	245,000	$5,309	12/31/2023
SAGE	245,000	$5,309	12/31/2023
Candriam Luxembourg S.C.A.	227,000	$4,919	12/31/2023
SAGE	227,000	$4,919	12/31/2023
StemPoint Capital LP	218,319	$4,731	12/31/2023
SAGE	218,319	$4,731	12/31/2023
UBS Group AG	203,204	$4,403	12/31/2023
SAGE	203,204	$4,403	12/31/2023
Healthcare of Ontario Pension Plan Trust Fund	201,107	$4,358	12/31/2023
SAGE	201,107	$4,358	12/31/2023
Integral Health Asset Management LLC	200,000	$4,334	12/31/2023
SAGE	200,000	$4,334	12/31/2023
Barclays PLC		$4,270	12/31/2023
SAGE	197,060	$4,270	12/31/2023
Put	27,000	$585	12/31/2023
Call	27,000	$585	12/31/2023
American Century Companies Inc.	174,743	$3,787	12/31/2023
SAGE	174,743	$3,787	12/31/2023
Pinnacle Associates Ltd.	168,573	$3,653	12/31/2023
SAGE	168,573	$3,653	12/31/2023
Bank of New York Mellon Corp	181,055	$3,393	03/31/2024
SAGE	181,055	$3,393	03/31/2024
PDT Partners LLC	148,796	$3,224	12/31/2023
SAGE	148,796	$3,224	12/31/2023
Nuveen Asset Management LLC	142,694	$3,092	12/31/2023
SAGE	142,694	$3,092	12/31/2023
Assenagon Asset Management S.A.	156,593	$2,935	03/31/2024
SAGE	156,593	$2,935	03/31/2024
Verition Fund Management LLC	132,500	$2,871	12/31/2023
SAGE	132,500	$2,871	12/31/2023
Jefferies Financial Group Inc.	128,800	$2,791	12/31/2023
SAGE	128,800	$2,791	12/31/2023
Citigroup Inc.	124,363	$2,695	12/31/2023
SAGE	124,363	$2,695	12/31/2023
Levin Easterly Partners LLC	122,643	$2,658	12/31/2023
SAGE	122,643	$2,658	12/31/2023