There is a long list of 99 institutional holders of KALV within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of KALV by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-KALV table below, the initial column indicates the name of each top institutional holder of KALV, with a link to that fund's top holdings. The next columns indicate the amount of KALV stock held by each of the institutional holders of KALV, followed by the KALV position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
VR Adviser LLC	4,092,731	$50,136	12/31/2023
KALV	4,092,731	$50,136	12/31/2023
Frazier Life Sciences Management L.P.	3,622,294	$44,373	12/31/2023
KALV	3,622,294	$44,373	12/31/2023
Tang Capital Management LLC	3,440,345	$42,144	12/31/2023
KALV	3,440,345	$42,144	12/31/2023
TCG Crossover Management LLC	3,395,495	$41,595	12/31/2023
KALV	3,395,495	$41,595	12/31/2023
Suvretta Capital Management LLC	2,684,005	$32,879	12/31/2023
KALV	2,684,005	$32,879	12/31/2023
BlackRock Inc.	2,242,025	$27,465	12/31/2023
KALV	2,242,025	$27,465	12/31/2023
Saturn V Capital Management LLC	1,807,563	$22,143	12/31/2023
KALV	1,807,563	$22,143	12/31/2023
Vanguard Group Inc.	1,781,419	$21,822	12/31/2023
KALV	1,781,419	$21,822	12/31/2023
Boxer Capital LLC	1,650,000	$20,212	12/31/2023
KALV	1,650,000	$20,212	12/31/2023
Jefferies Financial Group Inc.	1,080,000	$13,230	12/31/2023
KALV	1,080,000	$13,230	12/31/2023
Driehaus Capital Management LLC	1,028,568	$12,600	12/31/2023
KALV	1,028,568	$12,600	12/31/2023
Citadel Advisors LLC		$9,832	12/31/2023
KALV	783,698	$9,600	12/31/2023
Call	50,100	$614	12/31/2023
Put	31,200	$382	12/31/2023
Dimensional Fund Advisors LP	716,964	$8,783	12/31/2023
KALV	716,964	$8,783	12/31/2023
Adage Capital Partners GP L.L.C.	705,000	$8,636	12/31/2023
KALV	705,000	$8,636	12/31/2023
Geode Capital Management LLC	630,048	$7,719	12/31/2023
KALV	630,048	$7,719	12/31/2023
DAFNA Capital Management LLC	601,032	$7,363	12/31/2023
KALV	601,032	$7,363	12/31/2023
State Street Corp	537,102	$6,580	12/31/2023
KALV	537,102	$6,580	12/31/2023
Morgan Stanley	452,434	$5,542	12/31/2023
KALV	452,434	$5,542	12/31/2023
StemPoint Capital LP	423,174	$5,184	12/31/2023
KALV	423,174	$5,184	12/31/2023
Woodline Partners LP	346,863	$4,249	12/31/2023
KALV	346,863	$4,249	12/31/2023
Goldman Sachs Group Inc.		$4,051	12/31/2023
Call	243,600	$2,984	12/31/2023
KALV	87,099	$1,067	12/31/2023
Northern Trust Corp	326,496	$4,000	12/31/2023
KALV	326,496	$4,000	12/31/2023
Nan Fung Group Holdings Ltd	304,277	$3,727	12/31/2023
KALV	304,277	$3,727	12/31/2023
Silverarc Capital Management LLC		$3,579	12/31/2023
Call	180,400	$2,210	12/31/2023
KALV	111,734	$1,369	12/31/2023
Citigroup Inc.	281,909	$3,453	12/31/2023
KALV	281,909	$3,453	12/31/2023
Rosalind Advisors Inc.	287,985	$3,416	03/31/2024
KALV	287,985	$3,416	03/31/2024
Susquehanna International Group LLP		$2,906	12/31/2023
Call	288,200	$3,530	12/31/2023
Put	77,900	$954	12/31/2023
KALV	26,971	$330	12/31/2023
Caption Management LLC		$2,865	12/31/2023
Call	395,500	$4,845	12/31/2023
Put	326,600	$4,001	12/31/2023
KALV	165,000	$2,021	12/31/2023
Two Sigma Advisers LP	202,522	$2,481	12/31/2023
KALV	202,522	$2,481	12/31/2023
Two Sigma Investments LP	165,759	$2,031	12/31/2023
KALV	165,759	$2,031	12/31/2023
Opaleye Management Inc.	150,000	$1,838	12/31/2023
KALV	150,000	$1,838	12/31/2023
SG Americas Securities LLC	137,817	$1,688	12/31/2023
KALV	137,817	$1,688	12/31/2023
Ghost Tree Capital LLC	130,036	$1,593	12/31/2023
KALV	130,036	$1,593	12/31/2023
Affinity Asset Advisors LLC	125,969	$1,543	12/31/2023
KALV	125,969	$1,543	12/31/2023
AlphaCentric Advisors LLC	130,000	$1,542	03/31/2024
KALV	130,000	$1,542	03/31/2024
Group One Trading L.P.		$1,492	12/31/2023
Call	121,800	$1,492	12/31/2023
Connor Clark & Lunn Investment Management Ltd.	110,922	$1,359	12/31/2023
KALV	110,922	$1,359	12/31/2023
Bank of New York Mellon Corp	112,053	$1,329	03/31/2024
KALV	112,053	$1,329	03/31/2024
Walleye Capital LLC	97,830	$1,198	12/31/2023
KALV	97,830	$1,198	12/31/2023
D. E. Shaw & Co. Inc.	88,763	$1,087	12/31/2023
KALV	88,763	$1,087	12/31/2023
Charles Schwab Investment Management Inc.	80,451	$986	12/31/2023
KALV	80,451	$986	12/31/2023
Nuveen Asset Management LLC	71,067	$871	12/31/2023
KALV	71,067	$871	12/31/2023
Atom Investors LP	69,844	$856	12/31/2023
KALV	69,844	$856	12/31/2023
Healthcare of Ontario Pension Plan Trust Fund	51,500	$631	12/31/2023
KALV	51,500	$631	12/31/2023
State of Wisconsin Investment Board	51,100	$626	12/31/2023
KALV	51,100	$626	12/31/2023
FMR LLC	50,970	$624	12/31/2023
KALV	50,970	$624	12/31/2023
Rhumbline Advisers	45,361	$556	12/31/2023
KALV	45,361	$556	12/31/2023
Barclays PLC	42,531	$521	12/31/2023
KALV	42,531	$521	12/31/2023
Renaissance Technologies LLC	42,300	$518	12/31/2023
KALV	42,300	$518	12/31/2023
Campbell & CO Investment Adviser LLC	41,365	$507	12/31/2023
KALV	41,365	$507	12/31/2023