There is a long list of 215 institutional holders of XENE within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of XENE by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-XENE table below, the initial column indicates the name of each top institutional holder of XENE, with a link to that fund's top holdings. The next columns indicate the amount of XENE stock held by each of the institutional holders of XENE, followed by the XENE position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
Avoro Capital Advisors LLC	5,666,666	$261,007	12/31/2023
XENE	5,666,666	$261,007	12/31/2023
FMR LLC	5,655,922	$260,512	12/31/2023
XENE	5,655,922	$260,512	12/31/2023
Driehaus Capital Management LLC	4,345,180	$200,139	12/31/2023
XENE	4,345,180	$200,139	12/31/2023
Wellington Management Group LLP	4,162,654	$191,732	12/31/2023
XENE	4,162,654	$191,732	12/31/2023
Polar Capital Holdings Plc	3,066,628	$141,249	12/31/2023
XENE	3,066,628	$141,249	12/31/2023
Capital World Investors	2,681,537	$123,512	12/31/2023
XENE	2,681,537	$123,512	12/31/2023
Capital International Investors	2,455,683	$113,109	12/31/2023
XENE	2,455,683	$113,109	12/31/2023
Commodore Capital LP	2,167,793	$99,849	12/31/2023
XENE	2,167,793	$99,849	12/31/2023
Paradigm Biocapital Advisors LP	2,127,400	$97,988	12/31/2023
XENE	2,127,400	$97,988	12/31/2023
BlackRock Inc.	2,067,063	$95,209	12/31/2023
XENE	2,067,063	$95,209	12/31/2023
Pictet Asset Management Holding SA	2,040,400	$93,981	12/31/2023
XENE	2,040,400	$93,981	12/31/2023
Braidwell LP	1,647,311	$75,875	12/31/2023
XENE	1,647,311	$75,875	12/31/2023
First Light Asset Management LLC	1,645,490	$75,791	12/31/2023
XENE	1,645,490	$75,791	12/31/2023
Alliancebernstein L.P.	1,574,568	$72,525	12/31/2023
XENE	1,574,568	$72,525	12/31/2023
Marshall Wace LLP	1,528,648	$70,410	12/31/2023
XENE	1,528,648	$70,410	12/31/2023
Rock Springs Capital Management LP	1,255,577	$57,832	12/31/2023
XENE	1,255,577	$57,832	12/31/2023
Citadel Advisors LLC		$52,123	12/31/2023
XENE	1,266,844	$58,351	12/31/2023
Put	152,100	$7,006	12/31/2023
Call	16,900	$778	12/31/2023
Perceptive Advisors LLC	1,100,748	$50,700	12/31/2023
XENE	1,100,748	$50,700	12/31/2023
Adage Capital Partners GP L.L.C.	1,048,725	$48,304	12/31/2023
XENE	1,048,725	$48,304	12/31/2023
Baker BROS. Advisors LP	993,679	$45,769	12/31/2023
XENE	993,679	$45,769	12/31/2023
Janus Henderson Group PLC	966,065	$44,484	12/31/2023
XENE	966,065	$44,484	12/31/2023
T. Rowe Price Investment Management Inc.	891,149	$41,047	12/31/2023
XENE	891,149	$41,047	12/31/2023
BVF Inc. IL	890,072	$40,997	12/31/2023
XENE	890,072	$40,997	12/31/2023
Point72 Asset Management L.P.	875,065	$40,305	12/31/2023
XENE	875,065	$40,305	12/31/2023
Avidity Partners Management LP	815,993	$37,585	12/31/2023
XENE	815,993	$37,585	12/31/2023
Invesco Ltd.	719,718	$33,150	12/31/2023
XENE	719,718	$33,150	12/31/2023
Lord Abbett & CO. LLC	717,972	$33,070	12/31/2023
XENE	717,972	$33,070	12/31/2023
Loomis Sayles & Co. L P	708,295	$32,624	12/31/2023
XENE	708,295	$32,624	12/31/2023
TimesSquare Capital Management LLC	737,173	$31,735	03/31/2024
XENE	737,173	$31,735	03/31/2024
First Turn Management LLC	680,389	$29,291	03/31/2024
XENE	680,389	$29,291	03/31/2024
Great Point Partners LLC	600,000	$27,636	12/31/2023
XENE	600,000	$27,636	12/31/2023
Boxer Capital LLC	600,000	$27,636	12/31/2023
XENE	600,000	$27,636	12/31/2023
Orbimed Advisors LLC	550,000	$25,333	12/31/2023
XENE	550,000	$25,333	12/31/2023
Fiera Capital Corp	576,542	$24,820	03/31/2024
XENE	576,542	$24,820	03/31/2024
Jennison Associates LLC	563,952	$24,278	03/31/2024
XENE	563,952	$24,278	03/31/2024
Candriam Luxembourg S.C.A.	560,884	$24,146	03/31/2024
XENE	560,884	$24,146	03/31/2024
Affinity Asset Advisors LLC	460,000	$21,188	12/31/2023
XENE	460,000	$21,188	12/31/2023
Samlyn Capital LLC	421,155	$19,398	12/31/2023
XENE	421,155	$19,398	12/31/2023
Dimensional Fund Advisors LP	402,668	$18,547	12/31/2023
XENE	402,668	$18,547	12/31/2023
Goldman Sachs Group Inc.	376,302	$17,332	12/31/2023
XENE	376,302	$17,332	12/31/2023
Federated Hermes Inc.	346,596	$15,964	12/31/2023
XENE	346,596	$15,964	12/31/2023
Two Sigma Investments LP	340,015	$15,661	12/31/2023
XENE	340,015	$15,661	12/31/2023
Vanguard Group Inc.	323,495	$14,900	12/31/2023
XENE	323,495	$14,900	12/31/2023
Granahan Investment Management Inc. MA	302,581	$13,937	12/31/2023
XENE	302,581	$13,937	12/31/2023
Parkman Healthcare Partners LLC	294,788	$13,578	12/31/2023
XENE	294,788	$13,578	12/31/2023
Franklin Resources Inc.	293,825	$13,534	12/31/2023
XENE	293,825	$13,534	12/31/2023
Altium Capital Management LP	290,535	$13,382	12/31/2023
XENE	290,535	$13,382	12/31/2023
DAFNA Capital Management LLC	276,739	$12,747	12/31/2023
XENE	276,739	$12,747	12/31/2023
Boone Capital Management LLC	255,432	$11,765	12/31/2023
XENE	255,432	$11,765	12/31/2023
Two Sigma Advisers LP	252,700	$11,639	12/31/2023
XENE	252,700	$11,639	12/31/2023