There is a long list of 87 institutional holders of TSHA within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of TSHA by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-TSHA table below, the initial column indicates the name of each top institutional holder of TSHA, with a link to that fund's top holdings. The next columns indicate the amount of TSHA stock held by each of the institutional holders of TSHA, followed by the TSHA position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
FMR LLC	22,439,124	$39,717	12/31/2023
TSHA	22,439,124	$39,717	12/31/2023
RA Capital Management L.P.	18,472,503	$32,696	12/31/2023
TSHA	18,472,503	$32,696	12/31/2023
RTW Investments LP	16,893,185	$29,901	12/31/2023
TSHA	16,893,185	$29,901	12/31/2023
VR Adviser LLC	10,412,872	$18,431	12/31/2023
TSHA	10,412,872	$18,431	12/31/2023
Vanguard Group Inc.	6,195,567	$10,966	12/31/2023
TSHA	6,195,567	$10,966	12/31/2023
Avoro Capital Advisors LLC	4,355,555	$7,709	12/31/2023
TSHA	4,355,555	$7,709	12/31/2023
Baker BROS. Advisors LP	4,004,756	$7,088	12/31/2023
TSHA	4,004,756	$7,088	12/31/2023
Eversept Partners LP	3,780,714	$6,692	12/31/2023
TSHA	3,780,714	$6,692	12/31/2023
Tybourne Capital Management HK Ltd.	3,700,000	$6,549	12/31/2023
TSHA	3,700,000	$6,549	12/31/2023
Artal Group S.A.	3,663,104	$6,484	12/31/2023
TSHA	3,663,104	$6,484	12/31/2023
Acuta Capital Partners LLC	3,589,333	$6,353	12/31/2023
TSHA	3,589,333	$6,353	12/31/2023
Millennium Management LLC		$6,072	12/31/2023
TSHA	3,380,532	$5,984	12/31/2023
Call	50,000	$88	12/31/2023
TCG Crossover Management LLC	2,912,861	$5,156	12/31/2023
TSHA	2,912,861	$5,156	12/31/2023
BlackRock Inc.	2,699,238	$4,778	12/31/2023
TSHA	2,699,238	$4,778	12/31/2023
Point72 Asset Management L.P.	2,688,000	$4,758	12/31/2023
TSHA	2,688,000	$4,758	12/31/2023
Polar Capital Holdings Plc	2,518,909	$4,458	12/31/2023
TSHA	2,518,909	$4,458	12/31/2023
Citadel Advisors LLC		$4,117	12/31/2023
TSHA	2,297,556	$4,067	12/31/2023
Call	29,300	$52	12/31/2023
Put	1,400	$2	12/31/2023
Ghost Tree Capital LLC	2,100,000	$3,717	12/31/2023
TSHA	2,100,000	$3,717	12/31/2023
Susquehanna International Group LLP		$2,532	12/31/2023
TSHA	1,428,146	$2,528	12/31/2023
Call	35,100	$62	12/31/2023
Put	32,800	$58	12/31/2023
Price T Rowe Associates Inc. MD	1,227,333	$2,173	12/31/2023
TSHA	1,227,333	$2,173	12/31/2023
Schonfeld Strategic Advisors LLC	1,119,375	$1,981	12/31/2023
TSHA	1,119,375	$1,981	12/31/2023
Renaissance Technologies LLC	1,097,400	$1,942	12/31/2023
TSHA	1,097,400	$1,942	12/31/2023
Geode Capital Management LLC	985,421	$1,745	12/31/2023
TSHA	985,421	$1,745	12/31/2023
Sands Capital Ventures LLC	724,873	$1,283	12/31/2023
TSHA	724,873	$1,283	12/31/2023
Exome Asset Management LLC	693,300	$1,227	12/31/2023
TSHA	693,300	$1,227	12/31/2023
Alphabet Inc.	640,882	$1,134	12/31/2023
TSHA	640,882	$1,134	12/31/2023
Quantum Private Wealth LLC	639,520	$1,132	12/31/2023
TSHA	639,520	$1,132	12/31/2023
Palo Alto Investors LP	529,861	$938	12/31/2023
TSHA	529,861	$938	12/31/2023
Acadian Asset Management LLC	460,066	$813	12/31/2023
TSHA	460,066	$813	12/31/2023
Adage Capital Partners GP L.L.C.	420,000	$743	12/31/2023
TSHA	420,000	$743	12/31/2023
Citigroup Inc.	310,963	$550	12/31/2023
TSHA	310,963	$550	12/31/2023
Monaco Asset Management SAM	295,000	$522	12/31/2023
TSHA	295,000	$522	12/31/2023
EntryPoint Capital LLC	291,616	$516	12/31/2023
TSHA	291,616	$516	12/31/2023
Kovitz Investment Group Partners LLC	277,778	$492	12/31/2023
TSHA	277,778	$492	12/31/2023
Morgan Stanley	216,538	$383	12/31/2023
TSHA	216,538	$383	12/31/2023
Northern Trust Corp	213,721	$378	12/31/2023
TSHA	213,721	$378	12/31/2023
ADAR1 Capital Management LLC	209,000	$370	12/31/2023
TSHA	209,000	$370	12/31/2023
Prelude Capital Management LLC	189,876	$336	12/31/2023
TSHA	189,876	$336	12/31/2023
TD Asset Management Inc.	175,600	$311	12/31/2023
TSHA	175,600	$311	12/31/2023
State Street Corp	143,220	$253	12/31/2023
TSHA	143,220	$253	12/31/2023
Two Sigma Investments LP	136,973	$242	12/31/2023
TSHA	136,973	$242	12/31/2023
Chicago Partners Investment Group LLC	134,851	$239	12/31/2023
TSHA	134,851	$239	12/31/2023
Bank of America Corp DE	122,328	$217	12/31/2023
TSHA	122,328	$217	12/31/2023
Qube Research & Technologies Ltd	118,521	$210	12/31/2023
TSHA	118,521	$210	12/31/2023
Goldman Sachs Group Inc.	83,474	$148	12/31/2023
TSHA	83,474	$148	12/31/2023
Dynamic Advisor Solutions LLC	45,000	$129	03/31/2024
TSHA	45,000	$129	03/31/2024
Williams & Novak LLC	45,000	$129	03/31/2024
TSHA	45,000	$129	03/31/2024
Diametric Capital LP	68,871	$122	12/31/2023
TSHA	68,871	$122	12/31/2023
Squarepoint Ops LLC	63,477	$112	12/31/2023
TSHA	63,477	$112	12/31/2023
The Manufacturers Life Insurance Company	61,547	$109	12/31/2023
TSHA	61,547	$109	12/31/2023