There is a long list of 172 institutional holders of RYTM within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of RYTM by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-RYTM table below, the initial column indicates the name of each top institutional holder of RYTM, with a link to that fund's top holdings. The next columns indicate the amount of RYTM stock held by each of the institutional holders of RYTM, followed by the RYTM position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
Primecap Management Co. CA	8,052,648	$370,180	12/31/2023
RYTM	8,052,648	$370,180	12/31/2023
Baker BROS. Advisors LP	6,398,365	$294,133	12/31/2023
RYTM	6,398,365	$294,133	12/31/2023
BlackRock Inc.	6,351,750	$291,990	12/31/2023
RYTM	6,351,750	$291,990	12/31/2023
RA Capital Management L.P.	5,330,412	$245,039	12/31/2023
RYTM	5,330,412	$245,039	12/31/2023
Goldman Sachs Group Inc.	5,047,934	$232,054	12/31/2023
RYTM	5,047,934	$232,054	12/31/2023
Vanguard Group Inc.	3,226,938	$148,342	12/31/2023
RYTM	3,226,938	$148,342	12/31/2023
NEA Management Company LLC	2,909,956	$133,771	12/31/2023
RYTM	2,909,956	$133,771	12/31/2023
Frazier Life Sciences Management L.P.	2,371,304	$109,009	12/31/2023
RYTM	2,371,304	$109,009	12/31/2023
Federated Hermes Inc.	2,310,955	$106,235	12/31/2023
RYTM	2,310,955	$106,235	12/31/2023
State Street Corp	2,206,018	$101,411	12/31/2023
RYTM	2,206,018	$101,411	12/31/2023
Perceptive Advisors LLC	2,154,110	$99,024	12/31/2023
RYTM	2,154,110	$99,024	12/31/2023
Polar Capital Holdings Plc	1,750,000	$80,448	12/31/2023
RYTM	1,750,000	$80,448	12/31/2023
Commodore Capital LP	1,550,000	$71,254	12/31/2023
RYTM	1,550,000	$71,254	12/31/2023
Rock Springs Capital Management LP	1,522,893	$70,007	12/31/2023
RYTM	1,522,893	$70,007	12/31/2023
Pictet Asset Management Holding SA	1,163,961	$53,507	12/31/2023
RYTM	1,163,961	$53,507	12/31/2023
Geode Capital Management LLC	1,119,129	$51,452	12/31/2023
RYTM	1,119,129	$51,452	12/31/2023
Checkpoint Capital L.P.	730,000	$33,558	12/31/2023
RYTM	730,000	$33,558	12/31/2023
Janus Henderson Group PLC	621,892	$28,587	12/31/2023
RYTM	621,892	$28,587	12/31/2023
Opaleye Management Inc.	610,000	$28,042	12/31/2023
RYTM	610,000	$28,042	12/31/2023
Driehaus Capital Management LLC	598,905	$27,532	12/31/2023
RYTM	598,905	$27,532	12/31/2023
Price T Rowe Associates Inc. MD	572,297	$26,309	12/31/2023
RYTM	572,297	$26,309	12/31/2023
Cormorant Asset Management LP	550,000	$25,284	12/31/2023
RYTM	550,000	$25,284	12/31/2023
Orbimed Advisors LLC	536,642	$24,669	12/31/2023
RYTM	536,642	$24,669	12/31/2023
FMR LLC	529,130	$24,324	12/31/2023
RYTM	529,130	$24,324	12/31/2023
Northern Trust Corp	501,094	$23,035	12/31/2023
RYTM	501,094	$23,035	12/31/2023
VR Adviser LLC	495,983	$22,800	12/31/2023
RYTM	495,983	$22,800	12/31/2023
Caption Management LLC		$21,684	12/31/2023
Call	471,700	$21,684	12/31/2023
Charles Schwab Investment Management Inc.	397,685	$18,282	12/31/2023
RYTM	397,685	$18,282	12/31/2023
Jane Street Group LLC		$17,990	12/31/2023
Call	221,000	$10,159	12/31/2023
RYTM	184,359	$8,475	12/31/2023
Put	14,000	$644	12/31/2023
Voloridge Investment Management LLC	362,717	$16,674	12/31/2023
RYTM	362,717	$16,674	12/31/2023
Assenagon Asset Management S.A.	301,636	$13,866	12/31/2023
RYTM	301,636	$13,866	12/31/2023
Lord Abbett & CO. LLC	283,518	$13,033	12/31/2023
RYTM	283,518	$13,033	12/31/2023
Susquehanna International Group LLP		$12,717	12/31/2023
Call	271,000	$12,458	12/31/2023
RYTM	32,232	$1,482	12/31/2023
Put	26,600	$1,223	12/31/2023
Artisan Partners Limited Partnership	271,421	$12,477	12/31/2023
RYTM	271,421	$12,477	12/31/2023
Canada Pension Plan Investment Board	267,000	$12,274	12/31/2023
RYTM	267,000	$12,274	12/31/2023
Barclays PLC		$11,815	12/31/2023
RYTM	251,415	$11,558	12/31/2023
Call	5,600	$257	12/31/2023
National Bank of Canada FI	239,000	$10,786	12/31/2023
RYTM	239,000	$10,786	12/31/2023
Morgan Stanley	231,656	$10,649	12/31/2023
RYTM	231,656	$10,649	12/31/2023
UBS Asset Management Americas Inc.	209,938	$9,651	12/31/2023
RYTM	209,938	$9,651	12/31/2023
Victory Capital Management Inc.	182,297	$8,380	12/31/2023
RYTM	182,297	$8,380	12/31/2023
Bank of New York Mellon Corp	180,222	$8,285	12/31/2023
RYTM	180,222	$8,285	12/31/2023
Citadel Advisors LLC		$8,018	12/31/2023
RYTM	113,915	$5,237	12/31/2023
Call	73,900	$3,397	12/31/2023
Put	13,400	$616	12/31/2023
Silverarc Capital Management LLC	174,248	$8,010	12/31/2023
RYTM	174,248	$8,010	12/31/2023
Samsara BioCapital LLC	172,647	$7,937	12/31/2023
RYTM	172,647	$7,937	12/31/2023
Healthcare of Ontario Pension Plan Trust Fund	151,843	$6,980	12/31/2023
RYTM	151,843	$6,980	12/31/2023
Nuveen Asset Management LLC	143,669	$6,604	12/31/2023
RYTM	143,669	$6,604	12/31/2023
Wellington Management Group LLP	139,802	$6,427	12/31/2023
RYTM	139,802	$6,427	12/31/2023
Invesco Ltd.	135,731	$6,240	12/31/2023
RYTM	135,731	$6,240	12/31/2023
D. E. Shaw & Co. Inc.	128,492	$5,907	12/31/2023
RYTM	128,492	$5,907	12/31/2023
Rafferty Asset Management LLC	121,654	$5,592	12/31/2023
RYTM	121,654	$5,592	12/31/2023