There is a long list of 159 institutional holders of PTGX within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of PTGX by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-PTGX table below, the initial column indicates the name of each top institutional holder of PTGX, with a link to that fund's top holdings. The next columns indicate the amount of PTGX stock held by each of the institutional holders of PTGX, followed by the PTGX position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
BVF Inc. IL	5,744,848	$131,729	12/31/2023
PTGX	5,744,848	$131,729	12/31/2023
Farallon Capital Management LLC	5,734,430	$131,490	12/31/2023
PTGX	5,734,430	$131,490	12/31/2023
BlackRock Inc.	5,543,902	$127,122	12/31/2023
PTGX	5,543,902	$127,122	12/31/2023
RTW Investments LP	5,315,514	$121,885	12/31/2023
PTGX	5,315,514	$121,885	12/31/2023
Vanguard Group Inc.	3,153,916	$72,319	12/31/2023
PTGX	3,153,916	$72,319	12/31/2023
State Street Corp	2,729,929	$62,597	12/31/2023
PTGX	2,729,929	$62,597	12/31/2023
Point72 Asset Management L.P.	2,613,453	$59,926	12/31/2023
PTGX	2,613,453	$59,926	12/31/2023
Johnson & Johnson	2,449,183	$56,160	12/31/2023
PTGX	2,449,183	$56,160	12/31/2023
Kynam Capital Management LP	2,004,875	$45,972	12/31/2023
PTGX	2,004,875	$45,972	12/31/2023
Adage Capital Partners GP L.L.C.	1,291,701	$29,619	12/31/2023
PTGX	1,291,701	$29,619	12/31/2023
Jefferies Financial Group Inc.	1,270,561	$29,134	12/31/2023
PTGX	1,270,561	$29,134	12/31/2023
Geode Capital Management LLC	1,248,284	$28,626	12/31/2023
PTGX	1,248,284	$28,626	12/31/2023
Morgan Stanley	1,191,837	$27,329	12/31/2023
PTGX	1,191,837	$27,329	12/31/2023
Deutsche Bank AG	910,012	$20,867	12/31/2023
PTGX	910,012	$20,867	12/31/2023
Price T Rowe Associates Inc. MD	823,740	$18,889	12/31/2023
PTGX	823,740	$18,889	12/31/2023
Dimensional Fund Advisors LP	816,537	$18,724	12/31/2023
PTGX	816,537	$18,724	12/31/2023
683 Capital Management LLC	715,000	$16,395	12/31/2023
PTGX	715,000	$16,395	12/31/2023
Northern Trust Corp	550,139	$12,615	12/31/2023
PTGX	550,139	$12,615	12/31/2023
Eversept Partners LP	538,074	$12,338	12/31/2023
PTGX	538,074	$12,338	12/31/2023
Candriam Luxembourg S.C.A.	537,000	$12,314	12/31/2023
PTGX	537,000	$12,314	12/31/2023
Goldman Sachs Group Inc.	515,220	$11,814	12/31/2023
PTGX	515,220	$11,814	12/31/2023
StemPoint Capital LP	513,681	$11,779	12/31/2023
PTGX	513,681	$11,779	12/31/2023
FMR LLC	465,952	$10,684	12/31/2023
PTGX	465,952	$10,684	12/31/2023
Sio Capital Management LLC	460,044	$10,549	12/31/2023
PTGX	460,044	$10,549	12/31/2023
Charles Schwab Investment Management Inc.	455,321	$10,441	12/31/2023
PTGX	455,321	$10,441	12/31/2023
Mangrove Partners	439,314	$10,073	12/31/2023
PTGX	439,314	$10,073	12/31/2023
JPMorgan Chase & Co.	411,046	$9,425	12/31/2023
PTGX	411,046	$9,425	12/31/2023
Gratus Capital LLC	397,571	$9,116	12/31/2023
PTGX	397,571	$9,116	12/31/2023
Perceptive Advisors LLC	383,260	$8,788	12/31/2023
PTGX	383,260	$8,788	12/31/2023
Superstring Capital Management LP	379,143	$8,694	12/31/2023
PTGX	379,143	$8,694	12/31/2023
Citadel Advisors LLC		$7,693	12/31/2023
Call	342,600	$7,856	12/31/2023
Put	55,000	$1,261	12/31/2023
PTGX	47,864	$1,098	12/31/2023
Ikarian Capital LLC	319,000	$7,315	12/31/2023
PTGX	319,000	$7,315	12/31/2023
Nuveen Asset Management LLC	305,419	$7,003	12/31/2023
PTGX	305,419	$7,003	12/31/2023
Kennedy Capital Management Inc.	304,790	$6,989	12/31/2023
PTGX	304,790	$6,989	12/31/2023
UBS Asset Management Americas Inc.	289,079	$6,629	12/31/2023
PTGX	289,079	$6,629	12/31/2023
Deep Track Capital LP	275,201	$6,310	12/31/2023
PTGX	275,201	$6,310	12/31/2023
Checkpoint Capital L.P.	266,856	$6,119	12/31/2023
PTGX	266,856	$6,119	12/31/2023
Susquehanna International Group LLP		$6,065	12/31/2023
Call	188,400	$4,320	12/31/2023
PTGX	109,683	$2,515	12/31/2023
Put	33,600	$770	12/31/2023
Two Sigma Advisers LP	222,000	$5,090	12/31/2023
PTGX	222,000	$5,090	12/31/2023
Renaissance Technologies LLC	213,967	$4,906	12/31/2023
PTGX	213,967	$4,906	12/31/2023
Bank of New York Mellon Corp	203,177	$4,659	12/31/2023
PTGX	203,177	$4,659	12/31/2023
ADAR1 Capital Management LLC	200,859	$4,606	12/31/2023
PTGX	200,859	$4,606	12/31/2023
Driehaus Capital Management LLC	198,689	$4,556	12/31/2023
PTGX	198,689	$4,556	12/31/2023
Walleye Capital LLC	185,426	$4,252	12/31/2023
PTGX	185,426	$4,252	12/31/2023
Silvercrest Asset Management Group LLC	180,496	$4,139	12/31/2023
PTGX	180,496	$4,139	12/31/2023
Rafferty Asset Management LLC	167,795	$3,848	12/31/2023
PTGX	167,795	$3,848	12/31/2023
Two Sigma Investments LP	158,843	$3,642	12/31/2023
PTGX	158,843	$3,642	12/31/2023
Bank of America Corp DE	153,409	$3,518	12/31/2023
PTGX	153,409	$3,518	12/31/2023
UBS Group AG	150,867	$3,459	12/31/2023
PTGX	150,867	$3,459	12/31/2023
Millennium Management LLC	149,163	$3,420	12/31/2023
PTGX	149,163	$3,420	12/31/2023