There is a long list of 101 institutional holders of OPRX within the last two holding periods in our database of 13F filers, so we've sorted through to present to you just the top 50 institutional holders of OPRX by largest to smallest position reported in the institutional investor's latest 13F filing. In the institutional-holders-of-OPRX table below, the initial column indicates the name of each top institutional holder of OPRX, with a link to that fund's top holdings. The next columns indicate the amount of OPRX stock held by each of the institutional holders of OPRX, followed by the OPRX position size held by the institution, and finally the date of the quarterly 13F filing period the holdings data represents for that institution.

Holder	Amount	Position Size ($ in 1000's)	As of
First Light Asset Management LLC	1,727,298	$24,718	12/31/2023
OPRX	1,727,298	$24,718	12/31/2023
BlackRock Inc.	1,134,954	$16,241	12/31/2023
OPRX	1,134,954	$16,241	12/31/2023
Vanguard Group Inc.	1,021,002	$14,611	12/31/2023
OPRX	1,021,002	$14,611	12/31/2023
Divisadero Street Capital Management LP	949,550	$13,588	12/31/2023
OPRX	949,550	$13,588	12/31/2023
AWM Investment Company Inc.	820,042	$11,735	12/31/2023
OPRX	820,042	$11,735	12/31/2023
Blair William & Co. IL	741,104	$10,605	12/31/2023
OPRX	741,104	$10,605	12/31/2023
Kennedy Capital Management Inc.	490,685	$7,022	12/31/2023
OPRX	490,685	$7,022	12/31/2023
G2 Investment Partners Management LLC	468,120	$6,699	12/31/2023
OPRX	468,120	$6,699	12/31/2023
D. E. Shaw & Co. Inc.	462,507	$6,618	12/31/2023
OPRX	462,507	$6,618	12/31/2023
Samjo Management LLC	410,900	$5,880	12/31/2023
OPRX	410,900	$5,880	12/31/2023
Geode Capital Management LLC	378,513	$5,417	12/31/2023
OPRX	378,513	$5,417	12/31/2023
Rice Hall James & Associates LLC	401,882	$4,883	03/31/2024
OPRX	401,882	$4,883	03/31/2024
State Street Corp	320,559	$4,587	12/31/2023
OPRX	320,559	$4,587	12/31/2023
Credit Suisse AG	317,569	$4,544	12/31/2023
OPRX	317,569	$4,544	12/31/2023
Dimensional Fund Advisors LP	256,431	$3,670	12/31/2023
OPRX	256,431	$3,670	12/31/2023
Federated Hermes Inc.	182,985	$2,619	12/31/2023
OPRX	182,985	$2,619	12/31/2023
Northern Trust Corp	158,407	$2,267	12/31/2023
OPRX	158,407	$2,267	12/31/2023
Group One Trading L.P.		$2,112	12/31/2023
Call	147,600	$2,112	12/31/2023
Millrace Asset Group Inc.	133,936	$1,917	12/31/2023
OPRX	133,936	$1,917	12/31/2023
JPMorgan Chase & Co.	126,896	$1,816	12/31/2023
OPRX	126,896	$1,816	12/31/2023
Boothbay Fund Management LLC	125,228	$1,792	12/31/2023
OPRX	125,228	$1,792	12/31/2023
Bridgeway Capital Management Inc.	124,700	$1,784	12/31/2023
OPRX	124,700	$1,784	12/31/2023
Bullseye Asset Management LLC	122,588	$1,754	12/31/2023
OPRX	122,588	$1,754	12/31/2023
Citadel Advisors LLC		$1,742	12/31/2023
OPRX	112,245	$1,606	12/31/2023
Call	29,900	$428	12/31/2023
Put	20,400	$292	12/31/2023
Bank of New York Mellon Corp	106,308	$1,521	12/31/2023
OPRX	106,308	$1,521	12/31/2023
Perkins Capital Management Inc.	105,463	$1,509	12/31/2023
OPRX	105,463	$1,509	12/31/2023
Renaissance Technologies LLC	92,345	$1,321	12/31/2023
OPRX	92,345	$1,321	12/31/2023
Avenir Corp	88,260	$1,263	12/31/2023
OPRX	88,260	$1,263	12/31/2023
Morgan Stanley	77,928	$1,115	12/31/2023
OPRX	77,928	$1,115	12/31/2023
Point72 Asset Management L.P.	77,520	$1,109	12/31/2023
OPRX	77,520	$1,109	12/31/2023
Millennium Management LLC	69,931	$1,001	12/31/2023
OPRX	69,931	$1,001	12/31/2023
Victory Capital Management Inc.	58,707	$840	12/31/2023
OPRX	58,707	$840	12/31/2023
Bank of America Corp DE	55,696	$797	12/31/2023
OPRX	55,696	$797	12/31/2023
Greenwood Capital Associates LLC	54,675	$782	12/31/2023
OPRX	54,675	$782	12/31/2023
PEAK6 Investments LLC		$767	12/31/2023
Call	65,700	$940	12/31/2023
Put	12,100	$173	12/31/2023
Charles Schwab Investment Management Inc.	44,903	$643	12/31/2023
OPRX	44,903	$643	12/31/2023
American Century Companies Inc.	44,895	$642	12/31/2023
OPRX	44,895	$642	12/31/2023
Acadian Asset Management LLC	44,869	$641	12/31/2023
OPRX	44,869	$641	12/31/2023
Nuveen Asset Management LLC	44,035	$630	12/31/2023
OPRX	44,035	$630	12/31/2023
State of Wisconsin Investment Board	41,100	$588	12/31/2023
OPRX	41,100	$588	12/31/2023
Susquehanna International Group LLP		$528	12/31/2023
OPRX	21,611	$309	12/31/2023
Call	15,300	$219	12/31/2023
Two Sigma Advisers LP	35,000	$501	12/31/2023
OPRX	35,000	$501	12/31/2023
Squarepoint Ops LLC	30,971	$443	12/31/2023
OPRX	30,971	$443	12/31/2023
Royal Bank of Canada	29,298	$419	12/31/2023
OPRX	29,298	$419	12/31/2023
Legato Capital Management LLC	34,316	$417	03/31/2024
OPRX	34,316	$417	03/31/2024
Simplex Trading LLC		$409	12/31/2023
OPRX	18,531	$265	12/31/2023
Call	11,800	$168	12/31/2023
Put	1,700	$24	12/31/2023
Rhumbline Advisers	28,144	$403	12/31/2023
OPRX	28,144	$403	12/31/2023
Alliancebernstein L.P.	25,700	$368	12/31/2023
OPRX	25,700	$368	12/31/2023
Engineers Gate Manager LP	25,155	$360	12/31/2023
OPRX	25,155	$360	12/31/2023
Connors Investor Services Inc.	24,500	$351	12/31/2023
OPRX	24,500	$351	12/31/2023