On this page, we present all of the funds holding TSHA from our database of 13F filers, detailed in the table below. The first column indicates the name of each of the funds holding TSHA, with a link to that fund's top holdings. The next columns indicate the amount of TSHA stock held by each of the funds holding TSHA, followed by the TSHA position size held by the fund, and lastly the date of the quarterly filing period the data represents. In total, we count 86 funds holding TSHA within the last two filing periods in our coverage universe of 13F filers, with the largest position size having been reported by FMR LLC. For more details on the positions held by FMR LLC (or by any of the other funds holding TSHA), click the fund name in the "Holder" column of the funds-holding-TSHA table below.

Holder	Amount	Position Size ($ in 1000's)	As of
FMR LLC	22,439,124	$39,717	12/31/2023
TSHA	22,439,124	$39,717	12/31/2023
RA Capital Management L.P.	18,472,503	$32,696	12/31/2023
TSHA	18,472,503	$32,696	12/31/2023
RTW Investments LP	16,893,185	$29,901	12/31/2023
TSHA	16,893,185	$29,901	12/31/2023
VR Adviser LLC	10,412,872	$18,431	12/31/2023
TSHA	10,412,872	$18,431	12/31/2023
Vanguard Group Inc.	6,195,567	$10,966	12/31/2023
TSHA	6,195,567	$10,966	12/31/2023
Avoro Capital Advisors LLC	4,355,555	$7,709	12/31/2023
TSHA	4,355,555	$7,709	12/31/2023
Baker BROS. Advisors LP	4,004,756	$7,088	12/31/2023
TSHA	4,004,756	$7,088	12/31/2023
Eversept Partners LP	3,780,714	$6,692	12/31/2023
TSHA	3,780,714	$6,692	12/31/2023
Tybourne Capital Management HK Ltd.	3,700,000	$6,549	12/31/2023
TSHA	3,700,000	$6,549	12/31/2023
Artal Group S.A.	3,663,104	$6,484	12/31/2023
TSHA	3,663,104	$6,484	12/31/2023
Acuta Capital Partners LLC	3,589,333	$6,353	12/31/2023
TSHA	3,589,333	$6,353	12/31/2023
Millennium Management LLC		$6,072	12/31/2023
TSHA	3,380,532	$5,984	12/31/2023
Call	50,000	$88	12/31/2023
TCG Crossover Management LLC	2,912,861	$5,156	12/31/2023
TSHA	2,912,861	$5,156	12/31/2023
BlackRock Inc.	2,699,238	$4,778	12/31/2023
TSHA	2,699,238	$4,778	12/31/2023
Point72 Asset Management L.P.	2,688,000	$4,758	12/31/2023
TSHA	2,688,000	$4,758	12/31/2023
Polar Capital Holdings Plc	2,518,909	$4,458	12/31/2023
TSHA	2,518,909	$4,458	12/31/2023
Citadel Advisors LLC		$4,117	12/31/2023
TSHA	2,297,556	$4,067	12/31/2023
Call	29,300	$52	12/31/2023
Put	1,400	$2	12/31/2023
Ghost Tree Capital LLC	2,100,000	$3,717	12/31/2023
TSHA	2,100,000	$3,717	12/31/2023
Susquehanna International Group LLP		$2,532	12/31/2023
TSHA	1,428,146	$2,528	12/31/2023
Call	35,100	$62	12/31/2023
Put	32,800	$58	12/31/2023
Price T Rowe Associates Inc. MD	1,227,333	$2,173	12/31/2023
TSHA	1,227,333	$2,173	12/31/2023
Schonfeld Strategic Advisors LLC	1,119,375	$1,981	12/31/2023
TSHA	1,119,375	$1,981	12/31/2023
Renaissance Technologies LLC	1,097,400	$1,942	12/31/2023
TSHA	1,097,400	$1,942	12/31/2023
Geode Capital Management LLC	985,421	$1,745	12/31/2023
TSHA	985,421	$1,745	12/31/2023
Sands Capital Ventures LLC	724,873	$1,283	12/31/2023
TSHA	724,873	$1,283	12/31/2023
Exome Asset Management LLC	693,300	$1,227	12/31/2023
TSHA	693,300	$1,227	12/31/2023
Alphabet Inc.	640,882	$1,134	12/31/2023
TSHA	640,882	$1,134	12/31/2023
Quantum Private Wealth LLC	639,520	$1,132	12/31/2023
TSHA	639,520	$1,132	12/31/2023
Palo Alto Investors LP	529,861	$938	12/31/2023
TSHA	529,861	$938	12/31/2023
Acadian Asset Management LLC	460,066	$813	12/31/2023
TSHA	460,066	$813	12/31/2023
Adage Capital Partners GP L.L.C.	420,000	$743	12/31/2023
TSHA	420,000	$743	12/31/2023
Citigroup Inc.	310,963	$550	12/31/2023
TSHA	310,963	$550	12/31/2023
Monaco Asset Management SAM	295,000	$522	12/31/2023
TSHA	295,000	$522	12/31/2023
EntryPoint Capital LLC	291,616	$516	12/31/2023
TSHA	291,616	$516	12/31/2023
Kovitz Investment Group Partners LLC	277,778	$492	12/31/2023
TSHA	277,778	$492	12/31/2023
Morgan Stanley	216,538	$383	12/31/2023
TSHA	216,538	$383	12/31/2023
Northern Trust Corp	213,721	$378	12/31/2023
TSHA	213,721	$378	12/31/2023
ADAR1 Capital Management LLC	209,000	$370	12/31/2023
TSHA	209,000	$370	12/31/2023
Prelude Capital Management LLC	189,876	$336	12/31/2023
TSHA	189,876	$336	12/31/2023
TD Asset Management Inc.	175,600	$311	12/31/2023
TSHA	175,600	$311	12/31/2023
State Street Corp	143,220	$253	12/31/2023
TSHA	143,220	$253	12/31/2023
Two Sigma Investments LP	136,973	$242	12/31/2023
TSHA	136,973	$242	12/31/2023
Chicago Partners Investment Group LLC	134,851	$239	12/31/2023
TSHA	134,851	$239	12/31/2023
Bank of America Corp DE	122,328	$217	12/31/2023
TSHA	122,328	$217	12/31/2023
Qube Research & Technologies Ltd	118,521	$210	12/31/2023
TSHA	118,521	$210	12/31/2023
Goldman Sachs Group Inc.	83,474	$148	12/31/2023
TSHA	83,474	$148	12/31/2023
Dynamic Advisor Solutions LLC	45,000	$129	03/31/2024
TSHA	45,000	$129	03/31/2024
Williams & Novak LLC	45,000	$129	03/31/2024
TSHA	45,000	$129	03/31/2024
Diametric Capital LP	68,871	$122	12/31/2023
TSHA	68,871	$122	12/31/2023
Squarepoint Ops LLC	63,477	$112	12/31/2023
TSHA	63,477	$112	12/31/2023
The Manufacturers Life Insurance Company	61,547	$109	12/31/2023
TSHA	61,547	$109	12/31/2023
Bank of New York Mellon Corp	58,140	$103	12/31/2023
TSHA	58,140	$103	12/31/2023
LPL Financial LLC	58,060	$103	12/31/2023
TSHA	58,060	$103	12/31/2023
Jane Street Group LLC		$96	12/31/2023
TSHA	42,278	$75	12/31/2023
Call	11,600	$21	12/31/2023
Cubist Systematic Strategies LLC	48,434	$86	12/31/2023
TSHA	48,434	$86	12/31/2023
Redwood Wealth Management Group LLC	42,600	$75	12/31/2023
TSHA	42,600	$75	12/31/2023
Cannon Global Investment Management LLC	24,200	$69	03/31/2024
TSHA	24,200	$69	03/31/2024
JPMorgan Chase & Co.	36,484	$65	12/31/2023
TSHA	36,484	$65	12/31/2023
Connor Clark & Lunn Investment Management Ltd.	35,400	$63	12/31/2023
TSHA	35,400	$63	12/31/2023
Graham Capital Management L.P.	28,477	$50	12/31/2023
TSHA	28,477	$50	12/31/2023
Commonwealth Equity Services LLC	26,769	$47	12/31/2023
TSHA	26,769	$47	12/31/2023
Virtu Financial LLC	26,070	$46	12/31/2023
TSHA	26,070	$46	12/31/2023
Engineers Gate Manager LP	21,696	$38	12/31/2023
TSHA	21,696	$38	12/31/2023
China Universal Asset Management Co. Ltd.	21,622	$38	12/31/2023
TSHA	21,622	$38	12/31/2023
Lee Financial Co	20,000	$35	12/31/2023
TSHA	20,000	$35	12/31/2023
Prudential Financial Inc.	19,050	$34	12/31/2023
TSHA	19,050	$34	12/31/2023
Dynamic Technology Lab Private Ltd	17,389	$31	12/31/2023
TSHA	17,389	$31	12/31/2023
Two Sigma Securities LLC	17,202	$30	12/31/2023
TSHA	17,202	$30	12/31/2023
Capital Investment Advisors LLC	10,000	$29	03/31/2024
TSHA	10,000	$29	03/31/2024
Charles Schwab Investment Management Inc.	16,140	$29	12/31/2023
TSHA	16,140	$29	12/31/2023
XTX Topco Ltd	16,285	$29	12/31/2023
TSHA	16,285	$29	12/31/2023
Victory Capital Management Inc.	15,600	$28	12/31/2023
TSHA	15,600	$28	12/31/2023
Howard Capital Management Inc.	14,165	$25	12/31/2023
TSHA	14,165	$25	12/31/2023
Group One Trading L.P.		$24	12/31/2023
TSHA	12,032	$21	12/31/2023
Call	1,900	$3	12/31/2023
ProShare Advisors LLC	11,946	$21	12/31/2023
TSHA	11,946	$21	12/31/2023
Camelot Portfolios LLC	11,000	$19	12/31/2023
TSHA	11,000	$19	12/31/2023
Royal Capital Wealth Management LLC	10,665	$19	12/31/2023
TSHA	10,665	$19	12/31/2023
Lazard Asset Management LLC	8,805	$15	12/31/2023
TSHA	8,805	$15	12/31/2023
Quarry LP	8,000	$14	12/31/2023
TSHA	8,000	$14	12/31/2023
Wells Fargo & Company MN	7,429	$13	12/31/2023
TSHA	7,429	$13	12/31/2023
UBS Group AG	3,943	$7	12/31/2023
TSHA	3,943	$7	12/31/2023
Tower Research Capital LLC TRC	2,871	$5	12/31/2023
TSHA	2,871	$5	12/31/2023
Allworth Financial LP	1,000	$2	12/31/2023
TSHA	1,000	$2	12/31/2023
Proequities Inc.		$0	12/31/2023
Put	0	$0	12/31/2023
Call	0	$0	12/31/2023
TSHA	0	$0	12/31/2023
Signaturefd LLC	50	$0	12/31/2023
TSHA	50	$0	12/31/2023
Capital Advisors Ltd. LLC	79	$0	12/31/2023
TSHA	79	$0	12/31/2023
Advisor Group Holdings Inc.	134	$0	12/31/2023
TSHA	134	$0	12/31/2023
Morton Brown Family Wealth LLC	260	$0	12/31/2023
TSHA	260	$0	12/31/2023